Reference of 56741-34-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 56741-34-5 name is Methyl 5-amino-2-fluorobenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Step A: Methyl 5-{[(2,6-difluorophenyl)carbonyl]amino}-2-fluorobenzoate; To a solution of methyl 5-amino-2-fluorobenzoate (2.5 g, 14.8 mmol) (prepared according to literature precedence) in DCM (100 mL) at 0 0C, 2,6-difluorobenzoyl chloride (1.85 mL, 14.8 mmol) was added and the solution was allowed to stir for 30 min. The reaction mixture was quenched with H2O (50 mL). The organic layer was then washed with 1M NaOH (50 mL), dried over MgSO4, filtered and evaporated onto silica gel. The title compound of Step A was purified by chromatography, (25-100% EtOAc in hexanes). The title compound of Step A was obtained as a white solid in 69% yield (3.17 g). MS (ESI): 309.99 [M+H]+.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 5-amino-2-fluorobenzoate, and friends who are interested can also refer to it.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/76140; (2009); A1;,
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