Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 106896-49-5, name is Methyl 4-amino-3-bromobenzoate, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H8BrNO2
To a 250 mL round bottom flask equipped with a magnetic stir bar was added N,N-dimethylformamide or benzenesulfonyl chloride.Stir the solution for 20 minutes.The color of the solution turned pale yellow.Add methyl 4-amino-3-bromobenzoate,The mixture was stirred at room temperature for 30 minutes.A large amount of solid product is formed, and the solid is filtered.Wash with ether and dry in vacuo.The resulting solid was then transferred to another 250 mL round bottom flask and neutralized by the addition of NaOH solution and ethyl acetate. Transfer the solution to the funnel for separation.The inorganic layer was extracted with 2 x 100 mL of ethyl acetate.After merging the organic layers,It was washed with brine and dried over anhydrous sodium sulfate for 3 hr.That is, the intermediate 1 [(E)-N-(2-bromo-4-carbomethoxyphenyl)-N,N-dimethylformamidine].
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Zaozhuang College; Shandong Lunan Mei Chemical Engineering Technology Institute; Liu Xuejing; Han Ying; Yan Peng; Bie Fusheng; Shi Yijun; Cao Han; (12 pag.)CN110183384; (2019); A;,
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