These common heterocyclic compound, 136333-97-6, name is Methyl 4-(2-bromoethyl)benzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C10H11BrO2
EXAMPLE 13({[(1Z)-2,2-Diethyl-1-oxidohydrazono]amino}oxy)methyl 4-{2-[({2-chloro-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)carbamoyl]phenyl}sulphonyl)amino]ethyl}benzoateStep A: Methyl 4-{2-[(tert-butoxycarbonyl)({2-chloro-5-[(2-methyl-2,3-dihydro-1H-indol-1-yl)carbamoyl]phenyl}sulphonyl)amino]ethyl}-benzoateDissolve the compound obtained in Step A of Example 1 (1.04×10-2 mol) in acetonitrile (20 ml) and place the solution under stirring. Add diisopropylethylamine (1.24×10-2 mol) and then, after stirring for 10 minutes, intermediate 9 (2.20×10-2 mol) dissolved in acetonitrile (20 ml). Heat the mixture at 60 C. After 5 days, the reaction mixture is evaporated to dryness under reduced pressure. The residue obtained is chromatographed on a silica column using as eluant a 75/25 n-heptane/ethyl acetate mixture.The title product is obtained in the form of a pale yellow meringue.
The synthetic route of Methyl 4-(2-bromoethyl)benzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LES LABORATOIRES SERVIER; US2010/286225; (2010); A1;,
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