A new synthetic route of C7H13BrO2

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15848-22-3, name is 5-Bromopentyl acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 5-Bromopentyl acetate

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15848-22-3, name is 5-Bromopentyl acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 5-Bromopentyl acetate

1- (4-METHOXY-PHENYL)-3-TRIFLUOROMETHYL-1, 4,5, 6-tetrahydro- pyrazolo [3,4-c] pyridin-7-one (0.500 g, 1.606 mmol) was dissolved in N, N- DIMETHYLFORMAMIDE (20 mL) and cooled to 0 OC. Sodium hydride (60%, 0.161 g, 4.016 mmol) was added followed by 5-BROMOPENTYL acetate (0.535 mL, 3.213 MMOL). The reaction was stirred at rt overnight, quenched with IN hydrochloric acid (100 mL), EXTRACTED WITH ETHYL ACETATE (3100 ML), WASHED WITH WATER (2X1100 L), washed with brine (1X100 mL), dried over MGSO4, concentrated, and purified by flash CHROMATOGRAPHY USING 0-100% ETHYL ACETATE/HEXANES gradient as the eluent to afford 6- [1- (4-METHOXY-PHENYL)-7-OXO-3-TRIFLUOROMETHYL-1, 4,5, 7-TETRAHYDRO- pyrazolo [3, 4-c] pyridin-6-yl]-hexanoic acid methyl ester (0.699 g, 99%). The ester (0.800 g, 1. 82 mmol) was dissolved in tetrahydrofuran (40 mL), 1M lithium borohydride (3.64 ML, 3.64 mmol) was added, and the reaction was refluxed overnight. The reaction was quenched with water (150 mL), extracted with ethyl acetate (3X150 ML), washed with brine (1X150 mL), dried over MGSO4, concentrated, and purified by flash chromatography using 0-100% ethyl ACETATE/HEXANES as the eluent to afford 0.478 g (64%): 1H NMR (CDCl3) 8 7.44 (d, j=8. 8 Hz, 2H), 6.96 (d, j=9.2 Hz, 2H), 3.84 (s, 3H), 3.67 (t, j=6. 8 Hz, 2H), 3.61 (t, j=6. 4 Hz, 2H), 3.47 (t, j=7. 5 Hz, 2H), 3.00 (t, j=6. 8 Hz, 2H), 1.65-1. 50 (m, 4H), 1.45-1. 30 (m, 4H) ppm.

The synthetic route of 15848-22-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRYSTOL-MYERS SQUIBB COMPANY; WO2004/83177; (2004); A2;,
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