Synthetic Route of 13195-64-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 13195-64-7 name is Diisopropyl malonate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
To a solution of diisopropyl malonate (500 mg, 2.65 mmol, 1 equiv) and nitroso benzene (313 mg, 2.92 mmol, 1 equiv) in absolute ethanol (1.25 mL, 2.2M), a saturated ethanolic solution of NaOH was added dropwise until the blue color of the solution turns pale brown. The reaction mixture was allowed to stir for 10 minutes and the solvent was removed under reduced pressure and the crude product was purified by column chromatography to afford 39 as viscous yellow colored oily liquid (449 mg, 61 percent).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Diisopropyl malonate, and friends who are interested can also refer to it.
Reference:
Patent; WILLIAM MARSH RICE UNIVERSITY; KATTAMURI, Padmanabha Venkatesh; KURTI, Laszlo; (181 pag.)WO2018/213572; (2018); A1;,
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