Synthetic Route of 680217-71-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 680217-71-4 as follows.
A mixture of scheme 27 compound 4 (1.4 g, 7.07 mmol) and (2,6-difluoro-phenyl)-acetic acid ethyl ester (2.63 g, 14.14 mmol), CS2CO3 (6.9 g, 21.2 mmol), were dissolved in DMF. The reaction mixture was heated to 110 C and stirred for 4h. The mixture was evaporated in vacuo, the residue was purified by silica gel column chromatography (DCM/MeOH = 100/1 to 10/1) to give the scheme 27 compound 5 (410 mg, 17%) as a yellow solid.
According to the analysis of related databases, 680217-71-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.; WO2014/52365; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics