24812-90-6, name is Methyl 3-amino-4-methoxybenzoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: Methyl 3-amino-4-methoxybenzoate
Preparation of the compound of formula VII :; To a solution of METHYL-3-AMINO-4-METHOXYBENZOATE (a compound of FORMULA 11, AVAILABLE FROM INDOFINE CHEMICAL Company, INC., Somerset, New Jersey), (315 g, 1.74 mol) in 1 L MEOH, the crude enone VI (350 g,-2. 09 mol) was added. The reaction was stirred at room temperature for 30 minutes. After cooling to 0C for 1 hour, the solid was filtered and dried under vacuum to give the desired compound of formula Vil, methyl 4-methoxy-3- {[(E)-4-trifluoromethyl-3-oxo-1-butenyl] amino} benzoate, (500 g, 95% yield) as a yellow solid. 1H NMR (400 MHz, CDCI3) a 3.94 (s, 3H), 4.04 (s, 3H), 5.74 (d, J=8.0 Hz, 1H), 7.00 (d, J=8.8 Hz, 1H), 7.79 (dd, J=13. 2,8. 0 Hz, 1H), 7.87 (dd, J=8.8, 2.0 Hz, 1 H), 7.92 (d, J=2.0 Hz, 1 H), 11.01 (br, 1 H)
The synthetic route of 24812-90-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SCHERING CORPORATION; WO2005/28471; (2005); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics