Electric Literature of 54535-22-7,Some common heterocyclic compound, 54535-22-7, name is Diethyl 2-((phenylamino)methylene)malonate, molecular formula is C14H17NO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: A diphenyl ether solution of 2e-k (4 mmol) containingcatalytic 2-chlorobenzoic acid was heated by microwaveirradiation (250 C) for 1-2 h. After cooling, the reactionmixture was filtered and the precipitate 3e-k was washedwith n-hexane and water. Ethyl 4-oxo-1,4-dihydroquinoline-3-carboxylate (3e) Starting from 2e (5 g); Yield (cream powder): 3 g (75 %); m.p. 261-262 C; IR (KBr) numax 1400-1600 (aromatic), 1695(carbonyl), 3150 (N-H) cm-1; LC-MS (ESI) m/z 218.1 (M+H+), 240.1 (M+Na+); Calcd. for C12H11NO3: C, 66.35; H,5.10; N, 6.45. Found: 66.47; H, 5.22; N, 6.27.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Diethyl 2-((phenylamino)methylene)malonate, its application will become more common.
Reference:
Article; Hajimahdi; Zabihollahi; Aghasadeghi; Ashtiani, S. Hosseini; Zarghi; Medicinal Chemistry Research; vol. 25; 9; (2016); p. 1861 – 1876;,
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