In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 712317-32-3, name is 3-Azetidineacetic acid ethyl ester hydrochloride belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of 3-Azetidineacetic acid ethyl ester hydrochloride
General procedure: Compound 8 (81 mg, 0.19 mmol) and ethyl 2-(4-piperidinyl)acetate (36 mg, 0.21 mmol) were dissolved in dichloromethane (3 ml). To the solution, 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (44 mg, 0.23 mmol) and 1-hydroxybenzotriazole (9 mg, 0.06 mmol) were added, followed by stirring at room temperature for 3 h. The reaction mixture was diluted with chloroform and washed with satd NaHCO3 aq and brine. The organic layer was dried over Na2SO4, and then concentrated in vacuo. The residue was purified by preparative TLC (methanol-chloroform = 1:100) to give the title compound 9 (83 mg, 0.15 mmol, 77%).
The synthetic route of 712317-32-3 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ichikawa, Masanori; Ohtsuka, Masami; Ohki, Hitoshi; Haginoya, Noriyasu; Itoh, Masao; Sugita, Kazuyuki; Usui, Hiroyuki; Suzuki, Makoto; Terayama, Koji; Kanda, Akira; Bioorganic and Medicinal Chemistry; vol. 20; 9; (2012); p. 3072 – 3093;,
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