Reference of 41841-16-1,Some common heterocyclic compound, 41841-16-1, name is Methyl 2-(4-bromophenyl)acetate, molecular formula is C9H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of methyl 2-(4-bromophenyl)acetate (1 g, 4.36 mmol) in dry THF (20 mL)was added LiHMDS (5.23 mL, 1 M) dropwise at -78 C under N2. The mixture was stirred at 0C for 2 h. After Mel (1.23 g, 8.72 mmol) was added at -78 C, the mixture was stirred at 20 Cfor 16 h. Quenched with NH4C1 sat. and extracted with EtOAc. The organic was concentratedand purified by silica gel colunm (PE/EtOAc = 1/0 to 100/1) to give the title product (642 mg,yield 6 1%). MS (ES+) C10H11BrO2 requires: 243, found 244 [M+H].
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-(4-bromophenyl)acetate, its application will become more common.
Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; BROOIJMANS, Natasja; BRUBAKER, Jason, D.; FLEMING, Paul, E.; HODOUS, Brian, L.; KIM, Joseph, L.; WAETZIG, Josh; WILLIAMS, Brett; WILSON, Douglas; WILSON, Kevin, J.; (347 pag.)WO2017/181117; (2017); A1;,
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