Synthetic Route of 335599-07-0,Some common heterocyclic compound, 335599-07-0, name is Ethyl 3-oxa-bicyclo[3.1.0]hexane-6-carboxylate, molecular formula is C8H12O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(3-Oxa-bicyclo[3.1.0]hex-6-yl)-methanol (56)-A 1M solution of LiAlH4 in THF (16.77 mL, 16.77 mmol) was cooled in an ice-water/acetone bath and a solution of 56 (2.62 g, 16.77 mmol) in THF (25 mL) was added slowly with stirring. The reaction was warmed to RT over 30 min and stirred for 1 h. The reaction was quenched by slow portionwise addition of 4.8 g of Na2SO4.10H2O, Stirring was continued for additional 1 h after the vigorous reaction subsided. MgSO4 was added and solids were removed by filtration, rinsed with fresh THF and solvents evaporated. The residue was purified by SiO2 chromatography eluting with an EtOAc/hexane gradient (0 to 50% EtOAc) to afford 0.98 g (51.3%) of 56 as a colorless liquid.
The synthetic route of 335599-07-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Rotstein, David Mark; Melville, Chris Richard; US2008/249087; (2008); A1;,
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