Synthetic Route of 121-98-2, These common heterocyclic compound, 121-98-2, name is Methyl 4-methoxybenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The mixture of 4-methoxy methyl benzoate (33 g, 0.2 mol) and anhydrous hydrazine (7.7 g, 0.24 mmol) was heated to 140 C under nitrogen atmosphere, and reacted at the said temperature for 30 minutes. After cooled to the room temperature, the mixture was extracted with ethyl acetate (3×100 ml). The organic layer was dried over anhydrous sodium sulfate, and filtered, then concentrated under reduced pressure to give a crude product of intermediate compound 19 (30 g), which can be used for the next reaction step directly.
The synthetic route of 121-98-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Beijing Foreland Biopharma Co., Ltd.; ZHANG, Xingmin; WANG, Ensi; GUO, Jing; NIU, Shengxiu; DAI, Zhuolin; ZHENG, Nan; JI, Liping; WANG, Zhenfang; LIANG, Tie; EP2860176; (2015); A1;,
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