Some common heterocyclic compound, 99548-54-6, name is Methyl 3-bromo-2-methylbenzoate, molecular formula is C9H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 99548-54-6
[000576] Synthesis of 9: [000577] A mixture of 7 (228 mg, 1.0 mmol), 8 (288 mg, 1.4 mmol), Na2C03 (212 mg, 2 mmol) and Pd(PPh3)4 (115 mg, 0.10 mmol) in 2 mL of toluene, 2 mL of ethanol and 2 mL of water was stirred under N2 protection at 80 C for 17 hours concentrated in vacuo. The residue was diluted with ethyl acetate (50 mL), washed with water (30 mL) and brine (30 mL), dried over anhydrous Na2S04 and filtered. The filtrate was concentrated in vacuo and the residue was purified by silica gel chromatography (ethyl acetate: petroleum ether = 1 : 50) to give 9 as white oil (260 mg, yield: 83.8%). LC-MS m/z: 311.1 [M+H]+. LC-MS Purity (214 nm): > 96%; tR = 2.256 min.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 99548-54-6, its application will become more common.
Reference:
Patent; DANA-FARBER CANCER INSTITUTE, INC.; BRADNER, James; ERB, Michael; QI, Jun; (96 pag.)WO2016/196879; (2016); A1;,
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