Adding a certain compound to certain chemical reactions, such as: 431-47-0, name is Methyl 2,2,2-trifluoroacetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 431-47-0, Formula: C3H3F3O2
4-bromo-1-(secbutyl)-1H-pyrazole (1.0 g, 5.0 mmol) was dissolved in dry THF (15 mL) at -78 C under nitrogen and was stirred for 10min. n-BuLi (2.5 M in hexanes, 2.1 mL, 5.2 mmol) was added drop wise to the solution was stirred for 2 h at -78 C. After two hours, methyl trifluoroacetate (0.85 mL, 8.5 mmol) was added drop wise and stirred for 30 min at -78 C. The solution was then allowed to warm up to room temperature and let stir for overnight. The mixture was then quenched with NH4Cl (20mL) and extracted with ether (50 mL), and dried over MgSO4. After concentration in vacuo(note: remove shortly after the ether is removed, because the compound is quite volatile), the residue was purified with flash chromatography over silica gel (hexane: ether = 98:2) to yield the product as a liquid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2,2,2-trifluoroacetate, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Camerino, Eugene; Wong, Dawn M.; Tong, Fan; Koerber, Florian; Gross, Aaron D.; Islam, Rafique; Viayna, Elisabet; Mutunga, James M.; Li, Jianyong; Totrov, Maxim M.; Bloomquist, Jeffrey R.; Carlier, Paul R.; Bioorganic and Medicinal Chemistry Letters; vol. 25; 20; (2015); p. 4405 – 4411;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics