Synthetic Route of 2901-13-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2901-13-5, name is Ethyl 2-methyl-2-phenylpropanoate, This compound has unique chemical properties. The synthetic route is as follows.
4-Iodo-(1′-carboxy-1′-methyl)ethylbenzene. A mixture of (1′-ethoxycarbonyl-1′-methyl)ethylbenzene (28.0 g, 146 mmol), iodine (24.7 g), sodium iodate (7.1 g) and concentrated sulfuric acid (4 ML) in acetic acid (200 ML) was stirred and heated at 55 C for 90 hours.. The solvent was evaporated and the residue was partitioned between water and hexane.. The organic phase was washed with aqueous sodium thiosulfate, dried, filtered, and evaporated.. The residue was taken up in ethanol (200 ML) and water (100 ML), and potassium hydroxide (20 g) was added.. The mixture was heated under reflux for 5 hours, and cooled to rt.. The mixture was washed with hexane.. The aqueous phase was acidified with concentrated hydrochloric acid, and extracted with hexane.. The organic phase was dried, filtered and evaporated to give 4-iodo-(1′-carboxy-1′-methyl)ethylbenzene as a solid (19.6 g, 67 mmol, 46%).
The chemical industry reduces the impact on the environment during synthesis Ethyl 2-methyl-2-phenylpropanoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Boehringer Ingelheim Pharmaceuticals, Inc.; EP1171113; (2004); B1;,
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