Related Products of 178312-47-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 178312-47-5 as follows.
(Reference Example 1) 4,4-Difluorocyclohexanecarboaldehyde To a solution of 173 g (0.900 mol) of 4,4-difluorocyclohexanecarboxylic acid ethyl ester in 1.0 L toluene, 945 ml (0.945 mol) of 1.0 M diisobutyl aluminum hydride-toluene solution was added dropwise at -55C or lower temperatures and then the reaction solution was stirred at -65C for 30 minutes. After completion of the reaction, saturated ammonium chloride aqueous solution was added at -40C or lower temperatures to the reaction solution and then 1.0 L of 4 N hydrochloric acid was added at 0C or lower temperatures. The organic layer was separated and then the aqueous layer was extracted with toluene, and the combined organic layers were washed with 1 N hydrochloric acid, saturated sodium hydrogencarbonate aqueous solution and saturated sodium chloride aqueous solution in order and dried with anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure and the obtained oily residue was subjected to distillation under reduced pressure (55-57C/6 mmHg) to provide 75.3 g of the title compound as a colorless oil (yield: 57%). 1H-NMR spectrum (300 MHz, CDCl3) delta ppm: 9.68 (1H, d, J = 1 Hz), 2.42-2.28 (1H, m), 2.16-1.70 (8H, m).
According to the analysis of related databases, 178312-47-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Daiichi Sankyo Company, Limited; UBE Industries, Ltd.; KAWAI, Yukinori; IWASE, Noriaki; KIKUCHI, Osamu; TAKATA, Katsunori; MOTOYAMA, Takahiro; HAGIHARA, Masahiko; EP2801574; (2014); A1;,
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