Synthetic Route of 18448-47-0, These common heterocyclic compound, 18448-47-0, name is Methyl cyclohex-1-enecarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 4-Trifluoromethylbenzonitrile oxide (4) was generated as follows: a solution of the corresponding chloroxime (0.25g, 1.12mmol) in dry dichloromethane was passed through an Amberlyst-21 column and added dropwise over 30min to the solution of a dipolarophile in dry dichloromethane, and the solution was stirred overnight at room temperature. Water was added, organic layer was separated and the aqueous one extracted with dichloromethane. The combined organic layers were dried (MgSO4) and the product was purified by flash column chromatography.
Statistics shows that Methyl cyclohex-1-enecarboxylate is playing an increasingly important role. we look forward to future research findings about 18448-47-0.
Reference:
Article; Gucma, Miros?aw; Go??biewski, W. Marek; Michalczyk, Alicja K.; Journal of Molecular Structure; vol. 1060; 1; (2014); p. 223 – 232;,
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