The origin of a common compound about 14273-90-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14273-90-6, name is Methyl 6-bromohexanoate, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14273-90-6, name is Methyl 6-bromohexanoate, A new synthetic method of this compound is introduced below., category: esters-buliding-blocks

General procedure: Imidazole (2.0 equiv) in THF was treated with NaH (2.0 equiv). After 3 h at rt, the respective bromoalkanoic acid ester (1.0 equiv) was added and stirring was continued for the given time. Then, the reaction solution was filtered, evaporated, and purified by CC.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Hack, Silke; Wo?rlein, Babette; Ho?fner, Georg; Pabel, Jo?rg; Wanner, Klaus T.; European Journal of Medicinal Chemistry; vol. 46; 5; (2011); p. 1483 – 1498;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics