Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 126541-82-0, name is Methyl 3-amino-4-(trifluoromethyl)benzoate, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: Methyl 3-amino-4-(trifluoromethyl)benzoate
N-Chlorosuccinimide (8.2 g, 61 mmol) was added to a solution of methyl 3-amino-4- (trifluoromethyl)benzoate ( 13.2 g, 60.0 mmol) in acetonitrile (200 mL), and the resulting mixture was heated at 80 C for 20 h. After cooling, the mixture was partitioned between water (500 mL) and EtOAc (2 x 300 mL). The combined organic layers were washed with brine (200 mL), dried over anhydrous NaaSOzi, and concentrated. The residue was purified by column chromatography on silca gel (PE:EtOAc = 6: 1) to afford the title compound. MS: m/z = 254 (M + 1). lH NMR (400 MHz, CDC13) delta 7.49 (s, 1H), 7.17 (s, 1H), 3.92 (s, 3H).
According to the analysis of related databases, 126541-82-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MITCHELL, Helen; FRALEY, Mark E.; COOKE, Andrew J.; STUMP, Craig A.; ZHANG, Xu-Fang; MCCOMAS, Casey C.; SCHIRRIPA, Kathy; MCWHERTER, Melody; LIU, Chungsing; MAO, Qinghau; WO2015/143653; (2015); A1;,
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