Adding a certain compound to certain chemical reactions, such as: 344-14-9, name is Dimethyl 2-fluoromalonate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 344-14-9, Product Details of 344-14-9
Part A: 5-Fluoro-6-hydroxy-2,4(1H,3H)-pyrimidinedione. A mechanically stirred solution of urea (60.06 g, 1 mol) and dimethyl fluoromalonate (150.1 1 g, 1 mol) in methanol (1 L) was treated with 25 wt% NaOMe in methanol (-4.6M, 435 mL, 2 mol). The mixture was refluxed for 3 h and then allowed to cool to room temperature. The mixture was filtered, the wet cake was dissolved in warm water (-1.2L), and the resulting aqueous solution was acidified with concentrated aqueous HCI(-160 mL) to pH = 2 while stirring over 1 h. The mixture was allowed to cool to room temperature, and the product was filtered and washed thoroughly with water, then dried under vacuum to give 5-fluoro-6-hydroxy-2,4(1 H,3H)-pyrimidinedione (80 g, 55%) as a white solid. LCMS: (M+H)+: 147.0.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl 2-fluoromalonate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/61879; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics