In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 94994-25-9 as follows. category: esters-buliding-blocks
Method B. 1 (9.81 g, 0.0500 mol) was dissolved in THF (100 mL). Diethyl cyanomethyl- phosphonate (8.90 mL, 0.0550 mol) was added. The mixture was cooled with an ice bath. Sodium tert-butoxide (5.28 g, 0.0550 mol) was added slowly. After 10 min, the suspension became a clear solution. After 2 h, aq NaOH (1M, 50 mL) was added. The mixture was stirred at room temperature overnight. To the reaction mixture was added water (100 mL) and MTBE (100 mL). The aqueous layer was separated and washed with MTBE (100 mL) cooled with ice batch and acidified with HCI (2M, 50 mL). The precipitate was collected by filtration and dried in a vacuum oven at 50 C overnight to yield the product (3) as white solid (7.92 g) in 72.2% yield.
According to the analysis of related databases, 94994-25-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BIOGEN IDEC MA INC; KWOK, Daw-long, Albert; KIESMAN, William; HUMORA, Michael; CAI, Xiongwei; LITTKE, Adam; CHANG, HeXi; WO2011/63268; (2011); A2;,
Ester – Wikipedia,
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