4891-38-7, name is Methyl Phenylpropiolate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: esters-buliding-blocks
1.0 mmol (123.1 mg) of m-methoxyaniline and 1.0 mmol (160.2 mg) of methyl phenylpropiolate and1.2 mmol (122.4 mg) of phenylacetylene and0.005 mmol (1.8 mmol) of Cu (OTf)2catalystmg), HOTf 0.01mmol(1.5mg), a nitrile solvent has 2mL, deg.] C for 8h at 100 oil bath, cooled to room temperature, water was added 5mL, extracted with ethyl acetate threetimes, the organic layers were combined, concentrated under reduced pressure, the product after Purification by column chromatography, silica gel 300-400 mesh, eluantmixtureof ethyl acetate andpetroleum ether, the volume ratio of 1: 5, to obtain a white solid product 296.4mg, 95% yield, purity 99.9%
The synthetic route of 4891-38-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Nanyang Normal College; Zhang Xu; Xu Xuefeng; (13 pag.)CN106380463; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics