Related Products of 344-14-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 344-14-9, name is Dimethyl 2-fluoromalonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
First, put a stirrer in a 35 mL sealed tube, and then add 2-methyl-1-butene-3-yne (32 muL, 0.33 mmol), 0.9 mL tetrahydrofuran (0.9 mL), and 2-chloroacetamido Quinoline (66.2mg, 0.3mmol), dimethyl 2-fluoromalonate (70.4mg, 0.45mmol), to this mixed solution were added CuI (5.7mg, 0.03mmol) and Cs2CO3 (117.3mg, 0.36mmol), charge N2 for 3 minutes with a glass tube connected to nitrogen, fully drive out the air, seal the nozzle with a cock, and stir the reaction at 800C for 1.5 hours. After the reaction is completed, the system is cooled to room temperature and added to the reaction system. 2ml of distilled water was extracted with ethyl acetate. The organic phases were combined, and the solvent of the organic phase was distilled off under reduced pressure. 84.1 mg of product 4e was separated by silica gel column chromatography. The yield was 70%.
The synthetic route of Dimethyl 2-fluoromalonate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Anyang Normal University; Lv Yunhe; Pu Weiya; Wang Xin; Wang Xiaoxing; (15 pag.)CN110627718; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics