Application of 20372-66-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20372-66-1 as follows.
To a solution of 3-methoxyphenol (1 16 mg, 0.79 mmol) in DMSO (3 mL) was added potassium carbonate (218 mg, 1 .6 mmol) followed by methyl 2,4,5-trifluorobenzoate (150 mg, 0.79 mmol) . The resulting mixture was heated to 50C with stirring for 18 hours. The mixture was then cooled and diluted with water (30 mL) then washed with EtOAc (3 x 30 mL). The combined organic layers were dried over magnesium sulfate, filtered and concentrated in vacuo to afford the title compound (154 mg, 66%) as an orange gum. 1H NMR (400 MHz, CDCI3): delta ppm 3.81 (s, 3H), 3.92 (s, 3H), 6.61 -6.69 (m, 3H), 6.76- 6.81 (m, 1 H), 7.31 (t, 1 H), 7.76 (dd, 1 H). LCMS Rt = 1 .76 minutes MS m/z 295 [MH]+
According to the analysis of related databases, 20372-66-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER LIMITED; BROWN, Alan Daniel; GALAN, Sebastien Rene Gabriel; MILLAN, David Simon; RAWSON, David James; STORER, Robert Ian; STUPPLE, Paul Anthony; SWAIN, Nigel Alan; WO2013/102826; (2013); A1;,
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