Application of 6279-86-3,Some common heterocyclic compound, 6279-86-3, name is Triethyl methanetricarboxylate, molecular formula is C10H16O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of carbonyl compound (1.0-2.0 equiv) in CH2Cl2 or 1,2-dichloroethane, Tf2CHCH2CHTf2(5, 0.50 mmol) was added at room temperature. After stirring at room temperature to 80 C, the reaction mixture was concentrated under reduced pressure. The resultant residue was purified by bulb-to-bulb distillation using a Kugelrohr oven to give bis(triflyl)ethylated product 4.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Triethyl methanetricarboxylate, its application will become more common.
Reference:
Article; Yanai, Hikaru; Fujita, Masaya; Takahashi, Arata; Zhang, Min; Mishima, Masaaki; Kotani, Akira; Matsumoto, Takashi; Taguchi, Takeo; Molecules; vol. 18; 12; (2013); p. 15531 – 15540;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics