In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6933-47-7 as follows. HPLC of Formula: C9H11NO2
Intermediate 7.5.24-tert-Butoxycarbonylamino-2-methyl-benzoic acid methyl esterTo a stirred solution of intermediate 7.5.1 (1.5 g) in dioxane (15 ml) at 10 C. was added a solution of Boc anhydride (2.2 g) in dioxane (15 ml) dropwise and the reaction allowed to warm to rt. After 3 h, dimethylaminopyridine (catalytic amount) was added. After overnight stirring, the mixture was concentrated, and the residue was purified by flash chromatography (dichloromethan with ethanol gradient 0 to 4%) affording 0.69 g of the title compound.ESI mass spectrum: [M+H]+=266
According to the analysis of related databases, 6933-47-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/28938; (2012); A1;,
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