Related Products of 176694-36-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 176694-36-3, name is Methyl 4-fluoro-3-(trifluoromethyl)benzoate, This compound has unique chemical properties. The synthetic route is as follows.
To a solution of methyl 4-fluoro-3-(trifluoromethyl)benzoate (9.60 g, 43.2 mmol) in N,N-dimethylformamide (100 mL) was added mercaptan sodium (3.33 g, 47.5 mmol) at 0 C. by small portions, and the resulting mixture was stirred at room temperature for 2 hr. The reaction mixture was diluted with ethyl acetate, washed twice with water and once with saturated brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was recrystallized from hexane to give the title compound (10.1 g, yield 93%) as colorless crystals.melting point 76-77 C.1H NMR (CDCl3) delta 2.57 (3H, s), 3.94 (3H, s), 7.36 (1H, d, J=8.3 Hz), 8.11 (1H, dd, J=1.9, 8.3 Hz), 8.27 (1H, d, J=1.9 Hz).Elemental analysis (for C10H9F3O2S)Calculated (%): C, 48.00; H, 3.63.Found (%): C, 47.97; H, 3.62.
The chemical industry reduces the impact on the environment during synthesis Methyl 4-fluoro-3-(trifluoromethyl)benzoate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Itoh, Fumio; US2010/69381; (2010); A1;,
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