Synthetic Route of 14062-18-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 14062-18-1, name is Ethyl 2-(4-methoxyphenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: 55%NaH(3.29 g, 75.5mmol) was added to dried 1,4-dioxane (20 mL). After vigorously stirring at 30C under N2protection, compound 5 and substituted phenyl ethyl acetates (25.2mmol)were added slowly for 24 hours. After reaction, ethanol was dropped slowly in the mixture until no bubbles are produced. The crude mixture was evaporated invacuo. The residue was stirred vigorously in a biphasic mixture of water (200 mL) andEtOAc(300 mL) at 60C for 0.5 hour. After cooling to room temperature, the organic phase was dried over MgSO4and concentrated invacuo. Finally, the residual solid was recrystallized fromEtOActo afford the target compound6.
The chemical industry reduces the impact on the environment during synthesis Ethyl 2-(4-methoxyphenyl)acetate. I believe this compound will play a more active role in future production and life.
Reference:
Article; Huang, Xian-Feng; Cao, Yi-Jing; Zhen, Jing; Zhang, Da-Wei; Kong, Ren; Jiang, Wen-Tao; Xu, Ying; Song, Guo-Qiang; Ke, Heng-Ming; Liu, Li; Bioorganic and Medicinal Chemistry Letters; vol. 29; 3; (2019); p. 481 – 486;,
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