In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6279-86-3, name is Triethyl methanetricarboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of Triethyl methanetricarboxylate
Preparation of ethyl 1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylate In a round-bottomed flask equipped with a condenser, N-hexylaniline (355 mg, 2 mmol) is added to a solution of methanetricarboxylic acid triethyl ester (1.35 ml, 6.4 mmol). The resulting reaction mixture is placed in a CEM Discovery microwave oven and irradiated in the open round-bottomed flask, and then the ethanol formed is distilled off (the parameters are the following: power=250 W, temperature=225 C., execution time=5 min, hold time=15 min). After microwave heating, the reaction crude is purified on a chromatographic column, with petroleum ether, ethyl acetate at 4:1. The crystalline product obtained is dried to give the compound: yield=430 mg (69%). 1H NMR (CDCl3): delta 8.16 (d, J=8 Hz, 1H), 7.64 (m, 1H), 7.27-7.19 (m, 2H), 4.48 (q, J=8 Hz, 2H), 4.18 (t, J=8 Hz, 2H), 1.72-0.86 (m, 14H).
The synthetic route of 6279-86-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE; Ruat, Martial; Faure, Helene; Gorojankina, Tatiana; Mann, Andre; Taddei, Maurizio; Manetti, Fabrizio; Solinas, Antonio; US2013/267559; (2013); A1;,
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