Synthetic Route of 88709-17-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 88709-17-5 name is Ethyl 2-ethoxy-4-methylbenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The reaction kettle was charged with ethyl 4-methyl-2-ethoxybenzoate (2.08 g, 10 mmol), isopropanol (100 mL, 1.33 mol), 30% hydrogen peroxide (13.6 mL, 12 mmol), and copper fluoride (24.9 mg, 0.3 mmol), bis- (diphenylphosphine) ethylamine (132.9 mg, 0.3 mmol), charged with 2.0 MPa of CO, heated to reflux, and stirred for 10 hours. After cooling to room temperature, a 2 mol / L potassium hydroxide aqueous solution (30 mL) was added to the reaction solution after depressurization, and the reaction was stirred at 40 C for 6 hours. Then, cyclohexane (50 mL × 3) was added to wash the reaction solution. The reaction solution was neutralized with hydrochloric acid to a pH of 7 , Concentrated under reduced pressure to about 50 mL, acidified with hydrochloric acid to pH 3, a yellow solid precipitated, filtered, and the residue was recrystallized from toluene-petroleum ether to obtain a white solid intermediate (I) (1.87 g, yield: 74.1%).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 2-ethoxy-4-methylbenzoate, and friends who are interested can also refer to it.
Reference:
Patent; Hangzhou China-USA East China Pharmaceutical Co., Ltd.; Yu Rui; Hong Xuming; Zheng Min; Shao Qingling; (8 pag.)CN110483292; (2019); A;,
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