Related Products of 150529-73-0,Some common heterocyclic compound, 150529-73-0, name is Methyl 2-(3-bromophenyl)acetate, molecular formula is C9H9BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Tributyltin methoxide (28.3 mL, 98 mmol), the product of preparation 8 (15.0 g, 65mol), isopropenyl acetate (10.8 mL, 98 mmol), palladium (II) acetate (750 mg, 3.30 mmol) and tri-ortho-tolylphosphine (2.0 g, 6.5 mmol) were stirred together in toluene (75 mL) at 100C for 5 hours. After cooling, the reaction was diluted with ethyl acetate (150 mL) and 4M aqueous potassium fluoride solution (90mL), and stirred for 15 minutes. The mixture was filtered through Arbocele and the organic phase was separated and concentrated in vacuo. The residue was then purified by column chromatography on silica gel eluting with diethyl ether : pentane, 0: 100 to 25: 75, followed by dichloromethane to give the title compound as a pale yellow oil in 94% yield (12.6 g). 1H NMR (400MHz, CDCI3) : 6 : 2.15 (3H, s), 3.61 (2H, s), 3.69 (5H, s), 7.10-7. 13 (2H, m), 7.19 (1H, d), 7. 30 (1H, t). LRMS ESI : m/z 229 [M+Na] +.
The synthetic route of 150529-73-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PFIZER LIMITED; PFIZER INC; WO2005/92860; (2005); A1;,
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