Electric Literature of 5445-17-0, A common heterocyclic compound, 5445-17-0, name is Methyl 2-bromopropanoate, molecular formula is C4H7BrO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
The 2.50g (9.05mmol) of tert-butyl 2 – [(benzylamino) methyl] azetidine-1-carboxylate [racemate] was dissolved in dichloromethane (150ml), the 5.55ml (4.03g, 39.8mmol) of triethylamine and 3.04ml (4.53g, 27.1mmol) of methyl 2-bromo-propionate [racemate] was added and the mixture was stirred overnight at room temperature.Then 5.55ml (4.03g, 39.8mmol) of triethylamine and 3.04ml (4.53g, 27.1mmol) of methyl 2-bromopropionate [racemate] was added, and the mixture was at 40 stirred overnight.At 40 then added 5.55ml (4.03g, 39.8mmol) of triethylamine and 3.04ml (4.53g, 27.1mmol) of methyl 2-bromopropionate [racemate], and the mixture was stirred overnight.After cooling to room temperature, the mixture was diluted with dichloromethane and washed with water, and the phases were separated.The aqueous phase was extracted twice with dichloromethane and the combined organic phase was washed with saturated aqueous sodium chloride, dried over sodium sulfate, filtered, and then the solvent was removed under reduced pressure.The crude product obtained was purified as follows: silica gel chromatography (dichloromethane, then dichloromethane / methanol = 100: 1).Yield: 3.22g (94%, based on the theoretical value).
The synthetic route of 5445-17-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bayer Pharma AG; Aleihailigen, S.; Buhemilei, A.; Engeer, K.; Gedesi, C.; Gelike, K.M.; Gelishi, M.; Haitemaier, S.; Xilishi, A.; Jinceer, T.; Linao, P.; Lideer, B.; Leilixi, S.; Shimite, M.V.; Shitelasibuge, J.; Teshitegen, A.; (253 pag.)CN105431428; (2016); A;,
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