Adding a certain compound to certain chemical reactions, such as: 35065-86-2, name is 3-Bromophenyl acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 35065-86-2, Safety of 3-Bromophenyl acetate
In a 250 mL round bottom flask (8) (5.49 g, 26 mmol) and anhydrous AlCl3 (6.92 g, 51 mmol) was mixed thoroughly on oil bath at 160 C for 2 h. Reaction mixture was poured into ice water and concentrated hydrochloric acid solution was added to break complex formed during reaction. The mixture was taken in AcOEt (50 mL * 3). The organic layer was combined and washed with water and brine, and dried over Na2SO4. After filtration and concentration in vacuo, the residues was purified by silica gel flash chromatography (PE/AcOEt = 30:1) gave (9) (3.85 g, 70 %) as white solid. Mp: 36-38 C, MS (EI) [M]+: m/z = 213, 1H NMR (400 MHz, CDCl3) delta ppm: 7.60 (d, J = 8.0 Hz, 1H), 7.20 (s, 1H), 7.07 (d, J = 8.0 Hz, 1H), 2.63 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromophenyl acetate, and friends who are interested can also refer to it.
Reference:
Article; Wang, Chen; Gao, Hongping; Dong, Jinyun; Zhang, Yanmin; Su, Ping; Shi, Yaling; Zhang, Jie; Bioorganic and Medicinal Chemistry; vol. 22; 1; (2014); p. 277 – 284;,
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