These common heterocyclic compound, 57486-69-8, name is Methyl 2-(2-bromophenyl)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: esters-buliding-blocks
Example 1 Step 1 While stirring under a nitrogen atmosphere, methyl 2-(2- bromophenyl)acetate (2g), 4,4,4,,4,,5,5,5,,5,-octamethyl-2,2,-Bi-(1 ,3,2- dioxaborolane) (2.44g), and potassium acetate (0.98g) were added to a three- neck flask containing dioxane (25 mL). The resulting mixture was degassed with nitrogen for 15 minutes followed by addition of [1 ,1 – bis(diphenylphosphino)ferrocene]dichloropalladium(ll) (0.28g). After degassing with nitrogen for an additional 15 minutes, the mixture was stirred at 80C for 8 hr. After cooling to room temperature, the solvent was removed under vacuum and the crude residue was purified by silica gel chromatography. The mass spectrum of the resulting material was consistent with methyl 2-(2-(4,4,5,5- tetramethyl-1 ,3,2-dioxaborolan-2-yl)phenyl)acetate (2.41 g).
The synthetic route of Methyl 2-(2-bromophenyl)acetate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TRANSITIONS OPTICAL, INC.; DENG, Jun; STEPP, Brian, R.; SPITLER, Eric; XIAO, Wenjing; TAMASULO, Massimiliano; WALTERS, Robert, W.; (140 pag.)WO2016/144324; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics