Discovery of 14062-29-4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14062-29-4, name is Ethyl 2-(3-chlorophenyl)acetate, A new synthetic method of this compound is introduced below., Formula: C10H11ClO2

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 14062-29-4, name is Ethyl 2-(3-chlorophenyl)acetate, A new synthetic method of this compound is introduced below., Formula: C10H11ClO2

EXAMPLE 19 6-(3-Chlorobenzyl)-1-(2-trifluoromethylphenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one In analogy to the preparation of Example 9, 157 mg (70% of theory) of the desired product are obtained as a colourless solid starting from 0.15 g (0.56 mmol) of 5-amino-1-(2-trifluoromethylphenyl)-1H-pyrazole-4-carboxamide (Example 27A), 0.339 g (1.67 mmol) of ethyl (3-chlorophenyl)acetate and 0.111 g (2.78 mmol) of 60% sodium hydride. m.p.: 152 C. MS (ESI pos): m/z=405 (M+H)+ 1H-NMR (300 MHz, DMSO-d6): delta=3.9 (s, 2H), 7.15-7.5 (m, 4H), 7.6-8.05 (m, 4H), 8.3 (s, 1H), 12.5 (s, 1H) ppm.

The synthetic route of 14062-29-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bayer HealthCare AG; US2007/161662; (2007); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics