In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 185629-32-7, name is Methyl 4-amino-3-fluorobenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of Methyl 4-amino-3-fluorobenzoate
4-Amino-3-fluorophenylhydrazide. Methyl 4-amino-3 -fluorob enzoate (250 mg, 1.48 mmols) was added to a 10 mL round bottom flask with stir bar, followed by addition of anhydrous hydrazine (500 1iL, 15.9 mmols). The reaction was then heated to 70C under N2 for 15 hours. After cooling, the mixture was poured into deionized water (40 mL), and the resulting precipitate was filtered and rinsed with additional water (50 mL) to give the product as a tan solid (130 mg, 52%). ?HNIVIR (400 MHz; DMSO-d6) = 9.41 (s, 1H), 7.48 (dd, J=12.8 Hz, 1.7 Hz, 1H), 7.43 (dd, J= 8.6, 1.7 Hz, 1H), 6.74 (t, J= 8.6 Hz, 1H), 5.66 (br, 2H),4.36 (br s, 2H). ?3C NIVIR (100 MFIz; DMSO-d6) 5= 165.4, 149.5 (d, J= 236.8 Hz), 139.5 (d,J 12.9 Hz), 124.0, 120.3 (d, J 4.8 Hz), 114.8 (d, J 3.9 Hz), 113.7 (d, J 19.6 Hz). ?9FNMR (376 IVIHz; DMSO-d6) = -136.96 (dd, J= 12.0, 9.2 Hz). Referenced againstCF3COOHat -76.55 ppm. (ESI) m/z calcd for C7H8FN3O (M) 169.0645, found 169.1001.
The synthetic route of 185629-32-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; RAIKHEL, Natasha, V.; HICKS, Glenn, R.; ZHANG, Chunhua; (107 pag.)WO2017/49016; (2017); A1;,
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