These common heterocyclic compound, 25415-67-2, name is Ethyl 4-methylpentanoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C8H16O2
Under inert atmosphere, lithium diisopropylamide (4.457 g, 32 mmol) was dissolved in THF (250 ml.) and cooled to -78 C. Ethyl-4-methylvalerate (5.000 g, 35 mmol) was added dropwise and stirred at -78 C for 2 h. Benzyl bromide (7.1 16 g, 41.6 mmol) was added dropwise, stirred at – 78 C for 1 h and subsequently for 2 h at 25 C. Aq. sat. NH4CI solution was added and the or- ganic phase was extracted with MTBE, washed with water and brine, dried over MgS04, and evaporated. Column chromatography (S1O2; cyclohexane/ethyl acetate 2:1 ) yielded ethyl 2-ben- zyl-4-methyl-pentanoate (8.100 g, quant.) as colorless powder.
The synthetic route of Ethyl 4-methylpentanoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BASF SE; SEET, Michael; WOLF, Antje; MUELLER, Bernd; RIEDIGER, Nadine; FEHR, Marcus; MENTZEL, Tobias; GROTE, Thomas; RUDOLF, Georg Christoph; LOHMANN, Jan Klaas; WINTER, Christian; GRAMMENOS, Wassilios; WIEBE, Christine; TERTERYAN-SEISER, Violeta; ESCRIBANO CUESTA, Ana; (200 pag.)WO2019/154663; (2019); A1;,
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