Reference of 4720-83-6, These common heterocyclic compound, 4720-83-6, name is 6-Oxabicyclo[3.2.1]oct-3-en-7-one, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To 6-oxabicyclo [3.2. 1] oct-3-en-7-one (2.6 g, 21 mmol) in xylenes (50 ml) under nitrogen was added benzylamine (3.42 g, 32 mmol). The mixture was heated under reflux for 16 h, then cooled to room temperature. The heavy white precipitate was collected by filtration, and recrystallized from dichloromethane/hexane to give the amide as a white solid (3.8 g, 78%, m. p. 127- 128C)
The synthetic route of 4720-83-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TARGACEPT, INC.; WO2005/37832; (2005); A2;,
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