Adding a certain compound to certain chemical reactions, such as: 213598-10-8, name is Methyl 3-bromo-4-isopropoxybenzoate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 213598-10-8, Recommanded Product: Methyl 3-bromo-4-isopropoxybenzoate
Compound 22-1 (200 mg, 0.732 mmol) was dissolved in MeOH (5.00 mL). Lithium hydroxide monohydrate (61.5 mg, 1.46 mmol) and water (1.00 mL) were added. The mixture was stirred at 10 C. for 16 hours. The reaction solution was concentrated. The residue was added in water (3 mL) and extracted with dichloromethane (5 mL×1). The organic phase was discarded. The aqueous phase was adjusted to pH 5-6 with hydrochloric acid (1 mol/L), and extracted with dichloromethane (5 mL×2). The organic phase was dried over anhydrous sodium sulfate, filtered and concentrated to afford compound 22-2.1H NMR: (400 MHz, CDCl3) delta 8.31 (d, J=2.0 Hz, 1H), 8.02 (dd, J=2.0, 8.8 Hz, 1H), 6.94 (d, J=8.8 Hz, 1H), 4.81-4.61 (m, 1H), 1.44 (d, J=6.0 Hz, 6H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 3-bromo-4-isopropoxybenzoate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MEDSHINE DISCOVERY INC.; ZHANG, Peng; WU, Lingyun; YIN, Jun; LI, Jian; CHEN, Shuhui; (121 pag.)US2020/48235; (2020); A1;,
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