Some common heterocyclic compound, 326-58-9, name is Benzo[d][1,3]dioxol-5-yl acetate, molecular formula is C9H8O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C9H8O4
Acetic acid benzo[1,3]dioxol-5-yl ester 15 (2.51g, 13.93mmol) was dissolved in glacial acetic acid (5mL), then a solution of concentrated HNO3 1.1mL (70%, d=1.413, 1.09g, 17.27mmol) in glacial acetic acid (2mL) was added dropwise. The reaction mixture was stirred at rt for 4h, then was cooled at 0C. The yellow solid was filtrated, washed with cold water, air-dried, and used in the next step without further purification (2.95g, yield 94%). 1H NMR (300MHz, CDCl3) delta: 2.37 (s, 3H), 6.15 (s, 2H), 6.65 (s, 1H), 7.60 (s, 1H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 326-58-9, its application will become more common.
Reference:
Article; Brogi, Simone; Ramunno, Anna; Savi, Lida; Chemi, Giulia; Alfano, Gloria; Pecorelli, Alessandra; Pambianchi, Erika; Galatello, Paola; Compagnoni, Giulia; Focher, Federico; Biamonti, Giuseppe; Valacchi, Giuseppe; Butini, Stefania; Gemma, Sandra; Campiani, Giuseppe; Brindisi, Margherita; European Journal of Medicinal Chemistry; vol. 138; (2017); p. 438 – 457;,
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