Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 55099-31-5, name is Ethyl 10-bromodecanoate, A new synthetic method of this compound is introduced below., SDS of cas: 55099-31-5
1f. Preparation of Compound 6 A 3-neck 300 mL round-bottomed flask equipped with a reflux condenser, magnetic stir bar and a nitrogen inlet was charged with 4 g (1 equivalent) of 2-hydroxybenzonitrile, absolute ethanol 140 mL, and 12.54 mL (1 equivalent) of sodium ethoxide. This mixture was stirred at 25 C. for 15 minutes. Ethyl 10-bromodecanoate (9.4 g, 1 equiv.) was then added dropwise over 10 minutes. The resulting mixture was heated to reflux (75 C.) for 72 hours. The reaction mixture was cooled and the solids filtered off. The solvent was removed on a rotary evaporator. The crude residue was dissolved in ethyl acetate (300 mL) and washed with 1/2 saturated NaHCO3 (2*100 mL), H2O (1*100 mL) and brine (1*50 mL). The organic layer was dried to give 10 g of the crude ester. The crude material was then dissolved in ethanol (100 mL) and water (20 mL). LiOH (3.3 g) was added and the resulting mixture was heated to reflux (75 C.) for 3 hours. The solution was cooled and the solvent removed. 20 mL of H2O was added and the aqueous solution was acidified to a pH of about 3 with concentrated HCl. The solution was transferred to a 4 C. refrigerator to cool. A tan colored solid began to precipitate. This material was collected by vacuum filtration and dried on the high vacuum overnight to give the crude acid. These solids were further purified by recrystallization from ethyl acetate/hexanes (95/5) to give 7.1 g of the product, 10-(2-cyanophenoxy)decanoic acid (78% yield). Melting point: 82-84 C. Molecular Formula with water: C17H23NO3*0.0532. Combustion analysis: %C: 70.33 (calc’d), 69.82 (found); %H: 8.02(calc’d), 7.89(found); %N: 4.82 (calc’d), 4.82 (found).
The synthetic route of 55099-31-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Moye-Sherman, Destardi; Gschneidner, David; US2003/199427; (2003); A1;,
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