Electric Literature of 87661-20-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87661-20-9, name is tert-Butyl cyclopropanecarboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of (-R NH (4.74 mL, 33.2 mmol) in THF (40 mL) at 0C was added n-BuLi (13.3 mL of a 2.5M solution in hexanes, 33.2 mmol) portionwise. The LDA solution was stirred for 15 min at 0C, then was warmed to RT, and stirred for 30 min at RT, then was cooled to-78C. Tert-butyl cyclopropanecarboxylate (3.78 g, 26.6 mmol) was added dropwise over 10 min. The reaction was stirred at -78C for 2 h, after which l-bromopropane (4.84 mL, 53.2 mmol) was added dropwise over 20 min. The reaction was allowed to slowly warm to RT and stirred overnight at RT, then was quenched with satd aq. NH4Cl and extracted with EtOAc (2x). The combined organic extracts were washed with brine, dried (MgSCri), and concentrated in vacuo. The residue was distilled under reduced pressure (20 torr, BP = 95C) to give the title compound (2.99 g, 61 % yield) as an oil. NMR (500 MHz, CDCb) d 1.48 (m, 4H), 1.45 (s, 9H), 1.12 (m, 2H), 0.92 (m, 3H), 0.61 (m, 2H).
The synthetic route of tert-Butyl cyclopropanecarboxylate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; CHENG, Peter Tai Wah; KALTENBACH III, Robert F.; SHI, Jun; SHI, Yan; ZHANG, Hao; (0 pag.)WO2020/60915; (2020); A1;,
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