Some common heterocyclic compound, 41727-48-4, name is Methyl 4-amino-3,5-dichlorobenzoate, molecular formula is C8H7Cl2NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: Methyl 4-amino-3,5-dichlorobenzoate
EXAMPLE 5 1-Acetyl-2-(4-carbomethoxy-2,6-dichlorophenylimino)imidazolidine Methyl-4-amino-3,5-dichlorobenzoate (16.8 g, 31 mmole), 1-acetyl-2-imidazolidone (4.3 g, 33.5 mmole) in phosphoryl chloride (44 ml) were stirred at 50 C. for 3 days. After cooling the phosphoryl chloride was evaporated to give an oily residue. Iced water was added to the residue which was then basified with aqueous sodium hydroxide. The mixture was extracted with methylene chloride which was then washed with water, dried (magnesium sulphate) and evaporated to give a creamy solid. This solid was recrystallized from toluene to give the title compound (7.7 g) mp 188-189 C. Analysis calculated for C13 H13 Cl2 N3 O3: Theory: C, 47.30; H, 3.97; N, 12.73. Found: C, 47.34; H, 3.88; N, 12.60.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 41727-48-4, its application will become more common.
Reference:
Patent; Beecham Group p.l.c.; US4505926; (1985); A;,
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