Reference of 87808-49-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 87808-49-9, name is Methyl 2-bromo-4-methylbenzoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
(2) A suspension of the Compound 2 (4.0 g), the Compound 3 (3.52 g), [1,1?-bis(diphenylphosphino) ferrocene]palladium(II) dichloromethane adduct (1.43 g), and potassium carbonate (7.24 g) in N,N-dimethylformamide (80 mE) was stirred at 80 C. under a nitrogen atmosphere for 6 hours. To the reaction mixture was added diethyl ether (200 mE), and the resulting mixture was stirred, and then the resulting insoluble matters were removed by filtration. To the resulting filtrate were added water and ethyl acetate, and the resulting mixture was stirred, and then extracted with ethyl acetate. The resulting organic layers were washed with water and saturated brine, then dried, and concentrated under reduced pressure. The resulting residues were purified by silica gel column chromatography (hexane:ethyl acetate=95:5 to 80:20) to give the Compound 4 (2.78 g) as a pale yellow viscous material. MS (APCI): mlz 191 [M+H](3) To
The synthetic route of Methyl 2-bromo-4-methylbenzoate has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; SATO, Atsushi; IMASHIRO, Ritsuo; TSUJISHIMA, Hidekazu; TANIMOTO, Kouichi; YAMAMOTO, Yasuo; NAKANE, Tetsu; TOSHIKAWA, Chihiro; (118 pag.)US2018/258076; (2018); A1;,
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