Application of 2672-58-4,Some common heterocyclic compound, 2672-58-4, name is Trimethyl benzene-1,3,5-tricarboxylate, molecular formula is C12H12O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Take 8.00 g of trimesic acid methyl ester 35 oC dissolved in 80 mL of anhydrous tetrahydrofuran,Under nitrogen protection by a constant pressure funnel was slowly added dropwise to 3.00 g of lithium aluminum hydride and 300 mL of anhydrous tetrahydrofuran mixture,The dropwise addition was carried out in ice-salt bath, and the temperature was restored to room temperature after the addition was completed. The mixture was stirred at reflux for 70 oC for 24 h,The reaction was carried out under magnetically stirred ice bath-reflux integrated nitrogen protection. After the reaction, the reaction was quenched with about 100 mL of distilled water, the mixture was suction filtered, the filter cake was washed three times with 100 mL of methanol, and the filtrate was distilled under reduced pressure ,80 oC vacuum drying, 5.12 g are tribenzyl alcohol(96% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Trimethyl benzene-1,3,5-tricarboxylate, its application will become more common.
Reference:
Patent; Jilin Chemical College; Gao Wenxiu; Wang Jisi; Lou Dawei; Yu Dandan; Zhang Zhihui; Zhang Hao; (9 pag.)CN107501043; (2017); A;,
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