Synthetic Route of 29006-01-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 29006-01-7 name is Methyl 4-methoxybutanoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Methyl 4-methoxybutyrate 1a (1.6 g, 12.1 mmol) was added to 50 mL of tetrahydrofuran, and the temperature was lowered to -78 C.using a dry ice-acetone bath. Lithium bis-trimethylsilylamide (12.7mL) was addedslowly. 12.7 mmol). After completion of the addition, the reaction was stirred for 1 hour.Trimethylchlorosilane (1.31 g, 12.1 mmol) was added. The reaction was continued for 20 minutes with the addition of N-bromosuccinimide(2.15 g, 12.1 mmol). ), The reaction was stirred for 2 hours.The dry ice-acetone bath was removed, the temperature of the reaction solution was naturally raised to room temperature, thereaction was quenchedwith saturatedammonium chloride solution, the reaction solution was extracted with ethyl acetate (50 mL×3), the organic phases were combined, and the organic phases were separately used with water(50 mL). It was washed with sodium chloride solution (50 mL), dried over anhydrous sodium sulfate, filtered, and the filtrate was concentrated under reduced pressure.The resulting residue was purifiedby silica gel column chromatographyusing eluent system B to give the title product 1b (900 mg, colorless oil).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 4-methoxybutanoate, and friends who are interested can also refer to it.
Reference:
Patent; Jiangsu Hengrui Pharmaceutical Co., Ltd.; Shanghai Hengrui Pharmaceutical Co., Ltd.; Yang Fanglong; Chi Jiangtao; He Feng; Tao Weikang; (33 pag.)CN107793396; (2018); A;,
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