In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20637-08-5 as follows. Application In Synthesis of Methyl 4-(4-methoxyphenyl)butanoate
To a cooled solution of methyl 4- (4-methoxyphenyl) butyrate (3.6 g, 17.3 mmol) in CH2C12 (40 ml) at-78 C under N2 was added dropwise a solution of DIBAL in hexanes (1.0 M, 18.0 ml, 18 mmol). The resulting mixture was stirred at-78 C under N2 for 3 hrs, and then quenched by adding MeOH (-5 ml). The resulting mixture was warmed gradually to room temperature and filtered. The filtrate was concentrated in vacuo to give 4- (4-Methoxy-phenyl)-butyraldehyde as an oil (3.06 g, 100%). lH NMR (CDC13, 300 MHz) 8 1.91 (p, J = 7.5 Hz, 2H), 2.41 (t, J = 7.5 Hz, 2H), 2.58 (t, J = 7.5 Hz, 2H), 3.76 (s, 3H), 6.81 (d, J = 8.4 Hz, 2H), 8.07 (d, J = 8.4 Hz, 2H), 9.73 (s, 1H). The residue was used directly in the next step without any further purification.
According to the analysis of related databases, 20637-08-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; LA JOLLA PHARMACEUTICAL COMPANY; WO2005/82343; (2005); A2;,
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