Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2459-25-8, name is Methyl 2-naphthoate, A new synthetic method of this compound is introduced below., Formula: C12H10O2
Under a nitrogen atmosphere,Dissolve 50 g of methyl naphthalene-2-carboxylate in 350 mL of tetrahydrofuran.In a three-necked flask, the temperature of the system was reduced to -10C with liquid nitrogen.A 2mol/L solution of lithium diisopropylamide in tetrahydrofuran was added to the reaction system, wherein the volume of lithium diisopropylamide was 173.6mL, and then the temperature was raised to 20C and kept warm for 3 hours and then lowered to -80C and 87g was added. 1,2-Dibromoethane was reacted at -80C for 0.5 h, then allowed to stand at room temperature. The reaction solution was poured into a mixture of 500 mL of ethyl acetate and 2000 mL of a 10% volume aqueous solution of hydrochloric acid.After stirring for 10 minutes, let stand for 0.5h and discard the lower aqueous phase.The organic layer obtained from the upper layer was dried with 40 g of anhydrous sodium sulfate for 0.5 h.After filtration, the filtrate was distilled under reduced pressure at 45 C and -0.08 MPa until no solvent flowed out.The crude product of 3-bromonaphthalene-2-carboxylic acid methyl ester was obtained 69 g ,The crude product was added to 517 mL of ethanol and heated to reflux at 45 C. for 2 h.Then it was cooled to 0C for 1 h, filtered, and the filter cake was dried at 50C for 2 h.Obtained 66.5 g of 3-bromonaphthalene-2-carboxylic acid methyl ester, yield 93.5%, purity >98%.
The synthetic route of 2459-25-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanxi Laite Optoelectric Materials Co., Ltd.; Liu Ruigang; Zhang Wen; Li Jian; Li Lingang; Xue Zhen; Wang Yalong; (7 pag.)CN107602381; (2018); A;,
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