Sources of common compounds:

Reference of 18014-00-1, A common heterocyclic compound, 18014-00-1, name is Dimethyl 2,5-dibromoterephthalate, molecular formula is C10H8Br2O4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[Example 5] A mixed liquid of methyl p-dibromoterephthalate (Compound 1)(65.1 g, 185 mmol) synthesised according to the method of a literature (), thiopehne-2-boric acid (Compound 7)(made by Tokyo Chemical Industry Co., Ltd.)(71.0 g, 555 mmol), PdCl2(dppf)·CH2Cl2 (15.1 g, 18.5 mmol), potassium carbonate (84.4 g, 610 mmol) and toluene (6.5 L) was refluxed under a nitrogen atmosphere for 6 hours. After the reaction mixed liquid was allowed to cool to room temperature, water was added to the reaction mixed liquid, and the reaction mixed liquid was subjected to extraction with chloroform. The obtained organic layer was dried with sodium sulfate, and filtered, and thereafter, the solvent was distilled out under reduced pressure. The obtained mixture was recrystallized using hexane and chloroform to obtain dimethyl 2,5-bis(2-thienyl)terephthalate (Compound 8)(45.9 g, 128 mmol) in a yield of 69%. The physical properties of dimethyl 2,5-bis(2-thienyl)terephthalate (Compound 8) were as follows. 1H-NMR (CDCl3, delta ppm): 7.82 (s, 2H), 7.38 (dd, 2H), 7.07-7.12 (m, 4H), 3.78 (s, 6H)

The synthetic route of 18014-00-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sumitomo Chemical Company, Limited; EP2248818; (2010); A1;,
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