Reference of 2967-93-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2967-93-3 name is Methyl 2-fluoro-5-methylbenzoate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
(Table B1, B36, Scheme B2-B3) N-(3,4-dichlorobenzyl)-5-(((4,5-dihydro-1H-imidazol-2-yl)amino)methyl)-2-fluorobenzamide Bromination step: A solution of methyl 2-fluoro-5-methylbenzoate (2.10 g, 12.49 mmol) (CAS No.2967-93-3 Combi Blocks) in CCl4 (60 mL) was allowed to reflux through a Dean Stark trap to remove trace amounts of water. The solution was cooled to ambient temperature and treated with N-bromosuccinimide (NBS) (2.44 g, 13.74 mmol) and 2,2’azobis(2-methylpropionitrile (AIBN) (0.20 g, 1.20 mmol). The solution was heated to reflux for an 18 hour period. The mixture was cooled to ambient temperature, filtered and the resulting filtrate was concentrated under reduced pressure. The crude was then purified on silica gel using EtOAc/hexanes as mobile phase. The desired fractions where concentrated under reduced pressure to afford methyl 5-(bromomethyl)-2-fluorobenzoate compound 1.9 g (61%): 1H NMR (400 MHz, CDCl3) delta 8.0 (m, 1H), 7.6 (m, 1H), 7.1 (m, 1H), 4.5 (s, 2H), 4.0 (s, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Methyl 2-fluoro-5-methylbenzoate, and friends who are interested can also refer to it.
Reference:
Patent; Vanderbilt University; Gogliotti, Rocco D.; Stauffer, Shaun R.; Jeon, KyuOk; Salovich, James M.; Macdonald, Jonathan D.; Mills, Jonathan J.; Meyers, Kenneth M.; Alvarado, Joseph R.; Han, Changho; Fesik, Stephen W.; Lee, Taekyu; (177 pag.)US2020/55824; (2020); A1;,
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